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SASInstitute A00-281 : Clinical Trials Programming Using SAS 9 Accelerated Version Exam

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Test Number : A00-281
Test Name : Clinical Trials Programming Using SAS 9 Accelerated Version
Vendor Name : SASInstitute
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A00-281 exam Format | A00-281 Course Contents | A00-281 Course Outline | A00-281 exam Syllabus | A00-281 exam Objectives


Exam ID : A00-281
Exam Title : Clinical Trials Programming Using SAS 9 - Accelerated Version
Questions : 70 to 75
Pass Marks : 70%
Duration : 2 hours
Exam Type : Multiple Choice

Clinical Trials Process
Describe the clinical research process (phases, key roles, key organizations).
Interpret a Statistical Analysis Plan.
Derive programming requirements from an SAP and an annotated Case Report Form.
Describe regulatory requirements (principles of 21 CFR Part 11, International Conference on Harmonization, Good Clinical Practices).
Clinical Trials Data Structures
Identify the classes of clinical trials data (demographic, lab, baseline, concomitant medication, etc.).
Identify key CDISC principals and terms.
Describe the structure and purpose of the CDISC SDTM data model.
Describe the structure and purpose of the CDISC ADaM data model.
Describe the contents and purpose of define.xml.
Import and Export Clinical Trials Data
Apply regulatory requirements to exported SAS data sets (SAS V5 requirements).
Manage Clinical Trials Data
Access DICTIONARY Tables using the SQL procedure.
Examine and explore clinical trials input data (find outliers, missing vs. zero values, etc).
Transform Clinical Trials Data
Apply categorization and windowing techniques to clinical trials data.
Transpose SAS data sets.
Apply 'observation carry forward' techniques to clinical trials data (LOCF, BOCF, WOCF).
Calculate 'change from baseline' results.
Obtain counts of events in clinical trials.
Apply Statistical Procedures for Clinical Trials
Use SAS procedures to obtain descriptive statistics for clinical trials data (FREQ, UNIVARIATE, MEANS, SUMMARY).
Use PROC FREQ to obtain p-values for categorical data (2x2 and NxP test for association).
Use PROC TTEST to obtain p-values for continuous data (one-sample, paired and two-sample t-tests).
Create output data sets from statistical procedures.
Macro Programming for Clinical Trials
Create and use user-defined and automatic macro variables.
Automate programs by defining and calling macros.
Use system options to debug macros and display values of macro variables in the SAS log (MPRINT, SYMBOLGEN, MLOGIC, MACROGEN).
Report Clinical Trials Results
Use PROC REPORT to produce tables and listings for clinical trials reports.
Use ODS and global statements to produce and augment clinical trials reports.
Validate Clinical Trial Data Reporting
Explain the principles of programming validation in the clinical trial industry.
Utilize the log file to validate clinical trial data reporting.
Use programming techniques to validate clinical trial data reporting (PROC COMPARE, MSGLEVEL).
Identify and Resolve data, syntax and logic errors.



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expertise and Practices involving safe family unit cleansing and Disinfection for COVID-19 Prevention | A00-281 PDF download and exam Questions

abstract and creationIntroduction

A fresh report described a pointy increase in calls to poison centers involving exposures to cleaners and disinfectants in view that the onset of the coronavirus ailment 2019 (COVID-19) pandemic.[1] youngsters, statistics describing cleansing and disinfection practices within household settings within the united states are confined, in particular concerning these practices meant to avoid transmission of SARS-CoV-2, the virus that factors COVID-19. To deliver contextual and behavioral perception into the reported boost in poison center calls and to notify timely and valuable prevention thoughts, an choose-in web panel survey of 502 U.S. adults turned into performed in can also 2020 to symbolize expertise and practices related to family unit cleaning and disinfection all over the COVID-19 pandemic. capabilities gaps were recognized in a few areas, including secure education of cleansing and disinfectant options, use of advised very own protective gadget when using cleaners and disinfectants, and secure storage of hand sanitizers, cleaners, and disinfectants. Thirty-9 percent of respondents stated carrying out nonrecommended excessive-possibility practices with the intent of combating SARS-CoV-2 transmission, similar to washing meals items with bleach, applying household cleansing or disinfectant products to naked dermis, and intentionally inhaling or ingesting these items. Respondents who engaged in high-possibility practices more frequently said an antagonistic health impact that they believed turned into end result of the the usage of cleaners or disinfectants than did those that didn't report carrying out these practices. Public messaging should continue to emphasize proof-based mostly, safe practices corresponding to hand hygiene and counseled cleaning and disinfection of excessive-contact surfaces to prevent transmission of SARS-CoV-2 in family settings.[2] Messaging should also emphasize avoidance of high-possibility practices reminiscent of risky coaching of cleaning and disinfectant solutions, use of bleach on meals products, application of family unit cleansing and disinfectant products to skin, and inhalation or ingestion of cleaners and disinfectants.

Survey questions were administered via Porter Novelli Public features and ENGINE Insights on might also four, 2020, through PN View: 360,* a fast turnaround survey that will also be used to provide insights into skills and practices of targeted audiences. This decide-in information superhighway panel survey was administered to 502 U.S. adults aged ≥18 years the use of the Lucid platform;[3] panel members who had no longer taken a survey in the old 20 waves of survey administration were eligible to take part. Quota sampling and statistical weighting had been employed to make the panel representative of the U.S. inhabitants through gender, age, area, race/ethnicity, and education. Respondents were recommended that their answers were getting used for market analysis and will refuse to answer any question at any time. No for my part picking assistance was included in the statistics file provided to CDC.†

Survey questions requested about time-honored knowledge, attitudes, and practices regarding use of family unit cleaners and disinfectants§ and about selected information concerning cleansing and disinfection innovations for prevention of SARS-CoV-2 transmission. Weighted response frequencies were calculated using SAS statistical software (version 9.4; SAS Institute). as a result of respondents were recruited from an opt-in panel rather than by way of chance sampling, no inferential statistical tests were carried out.¶ adjustments had been cited when a difference of ≥5 percentage aspects changed into discovered between any estimates being compared.

The median age of respondents became forty six years (range = 18–86 years), and 52% of respondents have been female. overall, 63% of respondents were non-Hispanic white, 16% were Hispanic (any race), 12% were non-Hispanic black, and eight% have been multiracial or of different race/ethnicity. Respondents represented all U.S. Census regions,** with 38% from the South, 24% from the West, 21% from the Midwest, and 18% from the Northeast.

individuals had limited skills of safe preparation of cleaning and disinfectant options (determine 1). universal, 23% replied that most effective room temperature water should be used for education of dilute bleach solutions, 35% that bleach should still no longer be blended with vinegar, and 58% that bleach should no longer be mixed with ammonia. In assessment, a better percentage of respondents had talents about use of recommended very own defensive machine: 64% responded that eye coverage was counseled to be used of some cleaners and disinfectants, and 71% answered that gloves had been informed for use. similarly, 68% replied that handwashing changed into informed after using cleaners and disinfectants and seventy three% that sufficient air flow turned into counseled when the use of these products. involving safe storage of cleaners, disinfectants, and hand sanitizers, 79% of respondents referred to that cleaners and disinfectants should be stored out of the attain of babies, and 54% that hand sanitizers should still be kept out of the attain of infants.

determine 1.

capabilities about protected use of cleaners and disinfectants*,† based on responses to an opt-in information superhighway panel survey§ (N = 502 respondents) — u.s., may additionally 2020*in response to the query "Which of here have you ever heard is true about using household cleansing items (corresponding to bleach or Lysol)?"; response alternate options reflected CDC options for safe cleansing and disinfection. https://www.cdc.gov/coronavirus/2019-ncov/stay away from-getting-ailing/disinfecting-your-domestic.html.†In survey questions, the time period "cleansing" stated the usage of a cleaner or disinfectant on surfaces or objects. Questions involving storage of hand sanitizers had been covered with questions related to storage of cleaners and disinfectants.§Survey administered with the aid of Porter Novelli Public functions via PN View: 360; respondents might opt for varied responses to the question (all response alternate options shown). choice of the response "none of those" turned into exclusive (i.e., respondents couldn't opt for this response choice besides different responses).

Respondents said carrying out more than a few practices throughout the old month with the intent of preventing SARS-CoV-2 transmission (determine 2). Sixty p.c of respondents suggested greater generic home cleaning or disinfection in comparison with that in previous months. Thirty-nine % stated intentionally undertaking as a minimum one excessive-chance practice no longer advised by means of CDC for prevention of SARS-CoV-2 transmission,[2] including application of bleach to food objects (e.g., fruits and vegetables) (19%); use of family cleansing and disinfectant items on arms or epidermis (18%); misting the body with a cleansing or disinfectant spray (10%); inhalation of vapors from family cleaners or disinfectants (6%); and ingesting or gargling diluted bleach options, soapy water, and other cleaning and disinfectant solutions (four% each and every).

determine 2.

cleansing and disinfection practices within the previous month with the intent of fighting SARS-CoV-2 infection,*,† in response to responses to an opt-in internet panel survey§ (N = 502 respondents) — united states, might also 2020*in keeping with the query "during the past month, which of the following cleaning behaviors have you or a family unit member engaged in to steer clear of coronavirus?"†In survey questions, the time period "cleaning" talked about the use of a cleaner or disinfectant on surfaces or objects.§Survey administered via Porter Novelli Public capabilities via PN View: 360; respondents might opt for diverse responses to the query (9 of 11 feasible response alternate options shown). option of the response "none of these" become exclusive (i.e., respondents could not choose this response alternative besides other responses).

One quarter (25%) of respondents reported at least one adverse health effect during the old month that they believed had resulted from the use of cleaners or disinfectants, together with nose or sinus inflammation (11%); skin infection (eight%); eye inflammation (eight%); dizziness, lightheadedness, or headache (8%); upset stomach or nausea (6%); or breathing issues (6%). Respondents who stated engaging in as a minimum one excessive-risk follow greater commonly pronounced an opposed fitness effect than did folks that did not record accomplishing such practices (39% versus sixteen%).

about half (fifty one%) of respondents strongly agreed and 31% a bit agreed that they knew the way to clear and disinfect their domestic safely. similarly, forty two% strongly agreed and 35% just a little agreed that they knew the way to clean and disinfect their domestic to avoid SARS-CoV-2 transmission. When asked who their most trusted sources of SARS-CoV-2-connected cleansing and disinfection suggestions were, the precise three responses were CDC (65%), state or local health departments (49%), and doctors, nurses, or clinical suppliers (48%).


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